Multi-omics Approach to Evaluate the Effects of Carbamazepine During Zebra Mussel Spermatogenesis Under Environmental Conditions
This project investigated the molecular mechanisms underlying the reprotoxic effects of carbamazepine (CBZ) in Dreissena polymorpha at environmentally relevant concentrations. It aimed to clarify the role of sexual maturation in modulating pollutant effects and to explore the potential of multi-omics approaches as early and sensitive bioassays. Key objectives included assessing bioaccumulation in relation to spermatogenesis, identifying early molecular biomarkers of toxicity, and comparing responses under controlled and environmental conditions. The project also evaluated whether early omics signals could predict longer-term biological effects in freshwater bivalves. ...
Comparison of invasive and native populations of Dreissena polymorpha : effects of environmental impact
The CINPOP project falls within the '12. Climate action, environment, resource efficiency and raw materials' of Horizon 2020. France and Ukraine share a common freshwater fauna, in particular bivalve molluscs. Among them, Dreissena polymorpha is successfully distributed in Europe (including France) and North America as an invasive species from the Ponto-Caspian region, including Ukraine. In addition, the zebra mussel appears to be a bioindicator species that has already been used to amplify chemical or biological contamination of watercourses. The rate of accumulation and the biological responses to such contamination have made these molluscs interesting bioindicators of environmental pressures. The transplantation technique, which is easy to implement, means that this species can be actively monitored. The aim of CINPOP is to study the immunoreactivity of native and invasive mussels in order to understand and predict the general regularities of their dependence on new environmental impacts, particularly rising temperatures. ...
Rôle de la communication intercellulaire dans l’adaptation des cellules tumorales bronchiques présentant une altération de la voie RASSF1A/Hippo à leur microenvironnement
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L’ambition de l’"Ecoles universitaires de recherche" (EUR) Nano-PHOT est d’offrir une formation d’excellence unique d’ampleur internationale, en prise directe avec les enjeux scientifiques et socio-économiques liés à l’exploitation de la lumière à l’échelle nanométrique.
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Zebra Fish Embryo Assay for Toxicological riSk assessment
Chez les poissons, le test Easzy a permis de montrer que de nombreux PE sont capables de perturber, au stade embryonnaire, l’expression d’une enzyme, cytochrome P450 aromatase B, responsable de la synthèse des neuroestrogènes dans les cellules gliales radiaires. Ces cellules jouent un rôle important dans le développement du cerveau puisqu’elles donnent naissance à de nouvelles cellules dont certaines se différencient en neurones. La stratégie du projet FEATS repose sur la conduite d’expérimentations sur des modèles de poissons zèbres exposés à un panel de substances a priori connues pour avoir des effets sur l’expression du cytochrome P450 aromatase B afin d’explorer les effets sur le développement du cerveau et du comportement.
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Analyse préalable à une gestion durable des pêcheries de bouquet en Normandie
The project aims to conduct a targeted study of the European prawn (Palaemon serratus) using an ecosystem approach to fisheries in a context of global change. ...
Gonadal aromatase inhibition and other toxicity pathways leading to Fecundity Inhibition in Zebrafish: from initiating events to population impacts (GinFiz)
The GinFiz project aims to develop and test new methods to characterize the unintended effects of plant protection products on fish populations, particularly the impacts resulting from disruptions to individuals' endocrine systems.The overall goal of this project is the development and improvement of a quantitative Adverse Outcome Pathway (qAOP) leading to decreased fertility, in order to accurately predict the impacts of endocrine disruptors (EDs) across different biological levels — from internal accumulated doses to population-level effects.To achieve this, the project will pursue three main objectives:(i) Enhance the quantitative version of the aromatase A-based AOP, particularly to improve predictions of population-level impacts, using mechanistic mathematical models available at Ineris for zebrafish [18, 20], toxicological data generated by the AIDEZ project, and new data on steroid hormone dynamics.(ii) Integrate into this qAOP an additional toxicity pathway likely involving the progestogen signaling pathway, which may also lead to reduced zebrafish fertility.(iii) Use this qAOP and all generated data in a regulatory context to demonstrate its relevance for implementing the ECHA/EFSA guidance for identifying endocrine-disrupting properties. ...
Interspecies differences in response to endocrine disruptive chemicals
L’objectif du projet INDEE vise à caractériser et identifier des PE ayant une activité endocrinienne spécifique selon l’espèce cible (i.e. humain vs poisson zèbre) dans des effluents urbains et des eaux de rivières par une démarche bio-analytique utilisant une batterie de bioessais in vitro humains et de poisson permettant d’établir des profils d’activités multi-RN et, en combinaison avec des méthodes analytiques, d’identifier, au sein des mélanges, les molécules responsables d’effets inter-espèces.
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