CARMA

Multi-omics Approach to Evaluate the Effects of Carbamazepine During Zebra Mussel Spermatogenesis Under Environmental Conditions

2020 - 2022

This project investigated the molecular mechanisms underlying the reprotoxic effects of carbamazepine (CBZ) in Dreissena polymorpha at environmentally relevant concentrations. It aimed to clarify the role of sexual maturation in modulating pollutant effects and to explore the potential of multi-omics approaches as early and sensitive bioassays. Key objectives included assessing bioaccumulation in relation to spermatogenesis, identifying early molecular biomarkers of toxicity, and comparing responses under controlled and environmental conditions. The project also evaluated whether early omics signals could predict longer-term biological effects in freshwater bivalves.