Mélissa PALOS LADEIRO

My research can be divided into four axes, each with its own scientific questions and associated challenges:

• Axis 1: Role of immunomarkers in environmental biomonitoring: 
  Representativeness of innate immunity responses in biomonitoring of continental aquatic environments. Comparison of individual/conditional/spatio-temporal immune responses in invertebrates. Identification of parameters for the application of immune responses in biomonitoring and their implementation.
• Axis 2: Change of scale of immunomarkers
  Consideration of cellular and plasma responses in the immunity of bivalve invertebrates. Global and unbiased observation of innate immunity. Opening up to other species of invertebrates.
• Axis 3: Responses of immunomarkers in a context of multiple pressures
  Effects of chemical contaminants and biological pressures on immunomarkers. Understanding the interactions and mechanisms of action.
• Axis 4: Regulation of immunomarkers in invertebrates
  Define the links between immunity and other physiological functions (i.e., "immunity and nutrition" through food quality and energy distribution as well as with microbiota balance, "immunity and reproduction/endocrine system" through the modulation of immunomarkers with the life cycle of bivalves, etc.).
   

Project Coordinator:

• ORION, Interreg FWVL: Modeling the dynamics of microbiological and ecotoxicological pressures on transboundary water bodies using active monitoring of sentinel species and mathematical models, 2023. Collab. with U. Namur, U. Liège, INERIS, ACTALIA, ISSeP
• VENDETTA, ANSES: Antimicrobial Resistance Reactor: Role of Bivalves in the Production, Dissemination, and Monitoring of Antimicrobial Resistance in Aquatic Environments, 2023-2026. Collab. with UMR 7564 LCPME and UMR 5280 TRACES
• ACTION 1.2.4, MeSeine Innovation: Interest of dreissenid mussels for water body monitoring. (2021 - …)
• MicrobiEAU, Rhine-Meuse Water Agency: The dreissenid as an indicator of microbiological contamination of water bodies, 2021-2024. Collab. with UMR 7564 LCPME, ACTALIA, EA 7510 ESCAPE, and UMR 7360 LIEC
• CINPOP, PHC DNIPRO: Immunological and biochemical comparison of the resistance of invasive and native bivalve mollusks to environmental challengers, 2020-2021. Collab. with Prof. Oksana Stoliar (U. of Ternopil, Ukraine)
• BITWEEN, thesis by Héloïse Gendre: Study of the immune response of bivalves to chemical and biological challenges: comparative immunology in Mytilus edulis and Dreissena polymorpha, 2019-2022. Co-supervision with Yosra Ben Cheikh
• SENTINEL, ANSES: Surveillance of human Noroviruses and indicators of viral contamination in a public health context: development of an invertebrate enclosure approach coupled with modeling, 2020-2024. Collab with UMR 7564 LCPME, INRAE Lyon, UMR 5558 LBBE, ACTALIA
• MARTOX, Seine Normandy Water Agency: Toxicological and ecotoxicological impacts related to the destruction of the Martot dam, 2017-2019. Collab. with UMR 6143 M2C, U. Caen
• PROMÉTHÉE, thesis by Maxime Leprêtre: Proteomic Characterization by Mass Spectrometry of the Hemolymphatic Compartment of the Zebra Mussel Dreissena polymorpha, 2016-2019. Collab. with UMR 5280 of ISA Lyon, CEA DRF-Li2D of Marcoule.

Director of UMR-I 02 SEBIO (2024 - ...)

Scientific advisor for the company ELIDREO (2025 - …): https://elidreo.com/

Member of the board of SEFA: Society of Fundamental and Applied Ecotoxicology (2025 - …): https://asso-sefa.fr/societe-decotoxicologie-fondamentale-et-appliquee-sefa

Member of the Research Excellence axis of the International Institute for Bioeconomy and Environment, EXEBIO (2023 - …): https://www.exebio.fr/

Elected to the Scientific and Pedagogical Council of the ABIES doctoral school (2019 - …): https://abies.agroparistech.fr/

Coordinator of the Immune Defense axis at UMR-I 02 SEBIO (2019 – 2023)